Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 75
Filter
1.
Allergy: European Journal of Allergy and Clinical Immunology ; 78(Supplement 111):663, 2023.
Article in English | EMBASE | ID: covidwho-2301693

ABSTRACT

Background: Mastocytosis is a disorder characterized by an accumulation of mast cells in one or more organ systems and increased risk for severe anaphylaxis. Coronavirus disease 2019 (COVID-19) is associated with a relatively high rate of severe lung disease and mortality. During 2020, vaccines against COVID-19 were developed. The reported frequency of severe side effects appears to be low even in patients with severe allergies and mastocytosis. The aim of this study was to evaluate the safety of vaccines against COVID-19 in patients with mastocytosis. Method(s): Retrospective analysis of patients with a diagnosis of mastocytosis who have been vaccinated against COVID-19 in our department, from January to December 2021. Demographic data, history of anaphylactic reactions, COVID-19 vaccines used, premedication with antihistamines and hypersensitivity reactions were reviewed. Result(s): This study included 14 patients (64% (n = 9) were female, median age 51 +/- 18 years). Twelve (86%) patients had indolent systemic mastocytosis and two (14%) had cutaneous mastocytosis. Four (29%) patients had a history of idiopathic anaphylaxis, three (21%) reported anaphylaxis to hymenoptera venoms and one (7%) anaphylaxis to NSAID. The median basal serum tryptase level was 38.9 ng/ml, with a range from 12.7 to 91 ng/ml. Thirteen (93%) patients received an mRNA vaccine, and one adenoviral vector vaccine (7%), 2 doses each (28 administrations in total). None of the patients received premedication with antihistamines before the vaccination. None of the patients presented hypersensitivity reactions after the vaccine against COVID-19. Conclusion(s): As reported in recent studies, vaccination against COVID-19 in adult patients with mastocytosis is safe. Some authors recommend premedication in patients with mastocytosis at high risk for anaphylaxis. In our study, none of the patients received premedication and no hypersensitivity reactions were observed. More studies are needed, but in our sample, as observed for other vaccines, the vaccine against COVID-19 in patients with mastocytosis was safe.

2.
Finisterra ; 57(120):103-123, 2022.
Article in English, Portuguese | Scopus | ID: covidwho-2300447

ABSTRACT

After COVID-19, local and regional stakeholders need to generate conditions that will enable them to assert themselves in a climate of insecurity. The pandemic has triggered new paradigms of competitiveness, which drive various stakeholders linked to tourist destinations to stimulate business activity, supporting their economic viability. The key issue focuses not only on appeal to tourists, but also on attracting residents and businesses. Attracting innovative businesses involves knowing the motivations of entrepreneurs and what attributes they value in tourist destinations, which drives them to invest. To answer this objective, we developed a cross-sectional study, of exploratory nature, through a self- -administered survey by questionnaire, addressed to entrepreneurs in the Central Region of Portugal. Data were collected between January and May 2021, obtaining 138 responses. The questionnaire was submitted to reliability, and validation analyses and to principal component analysis (PCA). Matrices of variance and covariance (MANOVA) were analysed, aiming to test differences in responses between groups. The results suggest that ‘Resources' and the ‘Territorial brand' are determining factors in the investment of new businesses or the development of existing ones. In addition, conditions that influence the entrepreneurial initiative include the match between the entrepreneur's objectives and the characteristics of the territory, particularly the link between this and the identity of the region © Published under the terms and conditions of an Attribution-NonCommercial-NoDerivatives 4.0 International license.

3.
Omics Approaches and Technologies in COVID-19 ; : 405-425, 2022.
Article in English | Scopus | ID: covidwho-2295019

ABSTRACT

Digital and smart technologies have been widely used during the coronavirus disease 2019 (COVID-19) pandemic to control severe acute respiratory syndrome coronavirus 2 transmission, to perform rapid diagnosis, and for monitoring. Although the pandemic has caused economic, social, and diverse health problems, it has spurred developers of digital and smart technologies to fight the disease. Science and technology sectors constituting mainly of data science, machine learning, and artificial intelligence are contributing toward controlling the COVID-19 pandemic. Robots and smart technologies along with IoT (Internet of Things) structures have been digitizing the fight against the pandemic, which has enormous gains in terms of reducing contamination/transmission. This chapter provides a detailed revision about such technologies, describing and discussing their advantages, disadvantages, and limitations. We concluded that some of these innovative solutions, as they require the patient's personal information, are concerning authorities and researchers about ethical issues, such as data safety and personal privacy. Modern technologies have contributed to improving people's lives, presenting a significant advantage in helping people to control this infection. © 2023 Elsevier Inc. All rights reserved.

4.
Indian Journal of Occupational and Environmental Medicine ; 26(1):46, 2022.
Article in English | EMBASE | ID: covidwho-2260298

ABSTRACT

Introduction: Education system has faced lot of challenges during this covid 19 pandemic to ensure proper delivery of education to the students. In spite of the toughest hurdles faced by the education system, it has managed to reach out to students with the digital approach. Though a totally different approach from the traditional teaching, student's apprehension towards the change should not be ignored. Objective(s): To assess students view on online classes during the COVID 19 pandemic. Material(s) and Method(s): Study design: Qualitative descriptive cross-sectional study. Study setting: Fr. Agnel college, Pillar. Study participants:12th std students (2020-2021). Study tool: An online questionnaire using Likert scale was administered to the students. Assent/consent was taken before start of the study. Data was be analysed using SPSS software version 22. Result(s): Among the students participated 53% of students faced network issues,52% agreed that online education limited their participation in extracurricular activities. Majority of them faced health issues like eye strain, headache and disturbed sleep.

5.
J Intensive Care Med ; 38(7): 657-667, 2023 Jul.
Article in English | MEDLINE | ID: covidwho-2252895

ABSTRACT

Introduction: Critical care survivors sustain a variety of sequelae after intensive care medicine (ICM) admission, and the Coronavirus Disease 2019 (COVID-19) pandemic has added further challenges. Specifically, ICM memories play a significant role, and delusional memories are associated with poor outcomes post-discharge including a delayed return to work and sleep problems. Deep sedation has been associated with a greater risk of perceiving delusional memories, bringing a move toward lighter sedation. However, there are limited reports on post-ICM memories in COVID-19, and influence of deep sedation has not been fully defined. Therefore, we aimed to evaluate ICM-memory recall in COVID-19 survivors and their relation with deep sedation. Materials/Methods: Adult COVID-19 ICM survivors admitted to a Portuguese University Hospital between October 2020 and April 2021 (second/third "waves") were evaluated 1 to 2 months post-discharge using "ICU Memory Tool," to assess real, emotional, and delusional memories. Results: The study included 132 patients (67% male; median age = 62 years, Acute Physiology and Chronic Health Evaluation [APACHE]-II = 15, Simplified Acute Physiology Score [SAPS]-II = 35, ICM stay = 9 days). Approximately 42% received deep sedation (median duration = 19 days). Most participants reported real (87%) and emotional (77%) recalls, with lesser delusional memories (36.4%). Deeply sedated patients reported significantly fewer real memories (78.6% vs 93.4%, P = .012) and increased delusional memories (60.7% vs 18.4%, P < .001), with no difference in emotional memories (75% vs 80.4%, P = .468). In multivariate analysis, deep sedation had a significant, independent association with delusional memories, increasing their likelihood by a factor of approximately 6 (OR = 6.274; 95% confidence interval = 1.165-33.773, P = .032), without influencing real (P = .545) or emotional (P = .133) memories. Conclusions: This study contributes to a better understanding of the potential adverse effects of deep sedation on ICM memories in critical COVID-19 survivors, indicating a significant, independent association with the incidence of delusional recalls. Although further studies are needed to support these findings, they suggest that strategies targeted to minimize sedation should be favored, aiming to improve long-term recovery.


Subject(s)
COVID-19 , Deep Sedation , Adult , Humans , Male , Middle Aged , Female , Intensive Care Units , Deep Sedation/psychology , Aftercare , Patient Discharge , Critical Care/psychology , Survivors/psychology
6.
Pulmonology ; 2022 Jun 12.
Article in English | MEDLINE | ID: covidwho-2243471

ABSTRACT

The COVID-19 pandemic crisis, among so many social, economic and health problems, also brought new opportunities. The potential of telemedicine to improve health outcomes had already been recognised in the last decades, but the pandemic crisis has accelerated the digital revolution. In 2020, a rapid increase in the use of remote consultations occurred due to the need to reduce attendance and overcrowding in outpatient clinics. However, the benefit of their use extends beyond the pandemic crisis, as an important tool to improve both the efficiency and capacity of future healthcare systems. This article reviews the literature regarding telemedicine and teleconsultation standards and recommendations, collects opinions of Portuguese experts in respiratory medicine and provides guidance in teleconsultation practices for Pulmonologists.

7.
Pharmacien Clinicien ; 57(4):e139, 2022.
Article in French | EMBASE | ID: covidwho-2211255

ABSTRACT

Declaration de liens d'interets: Les auteurs declarent ne pas avoir de liens d'interets. Copyright © 2022

8.
Hematology, Transfusion and Cell Therapy ; 44(Supplement 2):S675-S676, 2022.
Article in English | EMBASE | ID: covidwho-2179239

ABSTRACT

Objetivo: O presente trabalho tem por objetivo investigar o gene NR3C1, que codifica os receptores de Glicocorticoide (GCs), em individuos com COVID-19. Material e Metodos: Foram analisadas 58 amostras de pacientes com COVID-19, atendidos em hospitais do municipio de Uberaba - MG entre maio de 2020 a junho de 2021. Este projeto foi aprovado pelo Comite de Etica em Pesquisa do Hospital de Clinicas da Universidade Federal do Triangulo Mineiro e todos os participantes assinaram o Termo de Consentimento Livre e Esclarecido. A amostra foi agrupada de acordo com o desfecho (alta ou obito) e gravidade da doenca (leve, moderada ou grave). A determinacao de gravidade dos casos foi realizada segundo os criterios estabelecidos no Manual de Manejo Clinico da COVID-19 da Organizacao Mundial de Saude. Foram coletados um tubo de 04 mL de sangue periferico na admissao do paciente e a quantificacao relativa do gene NR3C1 foi realizada por PCR em tempo real, utilizando o equipamento 7500 (Applied BiosystemsTM). O gene ACTB foi utilizado como controle endogeno. Os dados quantitativos foram submetidos ao teste de normalidade de Kolmogorov-Smirnov e as comparacoes estatisticas entre dois grupos realizadas com emprego do teste de Mann-Whitney. A significancia estatistica foi definida como p<0,05. Resultados: A idade mediana dos pacientes foi de 64,5 anos (min. 29, max. 100 anos). Dos 58 pacientes analisados, 26 eram mulheres e 32 homens. Em relacao ao desfecho, 31 obtiveram alta (17 mulheres 14 homens) e 27 evoluiram para obito (9 mulheres e 18 homens). Em relacao a gravidade, 13 pacientes tiveram quadro clinico leve (07 mulheres e 06 homens), 16 moderado (08 mulheres e 08 homens) e 29 grave (11 mulheres e 18 homens). Nao foi observada diferenca estatisticamente significativa na expressao do gene NR3C1 quanto ao desfecho ou gravidade (p=0,49 e p=0,25, respectivamente). Discussao: Acredita-se que a genetica humana tenha um importante papel na determinacao da resposta clinica ao SARS-CoV-2, no entanto, o estabelecimento dos mecanismos geneticos envolvidos na suscetibilidade ou resistencia a infeccao ainda nao sao completamente conhecidos. Os GCs inibem rapidamente a transcricao de citocinas pro-inflamatorias, como a IL-6. Essa citocina, por sua vez, esta envolvida num fenomeno denominado "tempestade de citocinas", em que ha uma exacerbacao da resposta imunologica. Na COVID-19 as manifestacoes de doenca grave e morte nao se apresentam exclusivamente pelos danos induzidos pelo virus nos pulmoes, mas tambem devido aos niveis elevados de citocinas, particularmente IL-6, que podem ser inibidas por GCs. Apesar do presente estudo nao ter observado diferenca na expressao do gene NR3C1 em relacao ao desfecho e gravidade, os receptores de GCs tem importante desempenho na supressao da "tempestade de citocinas". Alem disso, ja foi demonstrado que o uso de glicocorticoides em doses baixas e medias por ate oito dias e seguro e benefico para pacientes com COVID-19 grave. Conclusao: O presente estudo conclui que nao ha relacao entre a expressao do gene NR3C1 com o agravamento ou pior desfecho em pacientes com COVID-19. Copyright © 2022

9.
14th IEEE International Conference of Logistics and Supply Chain Management, LOGISTIQUA 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2161464

ABSTRACT

In several economic sectors, the COVID-19 has impacted the organisation of supply chain. Companies had to face a dramatic decrease in their order books. Traditional sales forecasting methods were unable to anticipate this abrupt interruption in the delivery of finished products. The production schedule initially planned was revised downwards and the raw materials ordered, according to an MRP-type calculation, were not consumed. The increase in raw material stocks, due to its importance on the companies' cash flow, became a strategic and priority issue. It was in this context that the aeronautical group Hutchinson set up an inventory segmentation based on an indicator: the just needed. Our article describes this method, known internally as Stock Segmentation Raw Material (SSRM), and assesses its advantages and limitations. © 2022 IEEE.

10.
Periplo Sustentable ; - (43):531-564, 2022.
Article in Spanish | Web of Science | ID: covidwho-2156713

ABSTRACT

The COVID-19 pandemic has generated a major global health crisis. It has also been reported that its impact has been greater in the specific case of tourism, compared to the economy as a whole. Cancun, the highly positioned Mexican sun and beach destination, has an economy concentrated on tourism, which magnified the impacts of the contingency measures applied, particularly on the vulnerability of workers in the sector. The objective of this work is to identify the impacts on the social vulnerability of tourism workers in Cancun, derived from contingency measures during the shock of the pandemic in 2020. The research consisted of a quantitative study through a survey not probabilistic and convenience focused on working conditions, habitability and emotionality of workers in tourist services. The results allowed us to recognize the high, medium and low levels of impact on the social vulnerability of workers, with the average vulnerability being the highest proportion in the case of Cancun.

11.
European Psychiatry ; 65(Supplement 1):S535-S536, 2022.
Article in English | EMBASE | ID: covidwho-2154092

ABSTRACT

Introduction: Evidence suggest that critically ill COVID-19 patients are at higher risk of developing anxiety symptoms, which may be related to or exacerbated by patients concerns regarding their health status and recovery. Objective(s): To assess anxiety symptoms in critically ill COVID-19 survivors, 1-2 months after hospital discharge and to analyze its association with concerns reported by patients regarding their own health status and recovery. Method(s): In the framework of MAPA prospective research, this preliminary study included COVID-19 patients admitted in the Intensive Care Medicine Department (ICMD) of a University Hospital. Patients were excluded if they had an ICMD length of stay (LoS) <=24h, terminal illness, major auditory impairment or inability to communicate at the evaluation time. Participants were assessed at a scheduled telephone follow-up appointment, with Generalized Anxiety Disorder Scale (GAD-7). Additional questions were asked to assess the survivors' post-discharge concerns regarding discrimination against for COVID-19, infection of a family member, re-infection or sequelae related to COVID-19. Result(s): Eighty-three patients were included (median age=63 years;63% male) and 24% had anxiety symptoms. Anxiety scores were higher in survivors who reported being afraid of being discriminated against for COVID-19 (30% vs 10%;p=0.034), being re-infected (100% vs 79%;p=0.032) and having sequelae (94% vs 44%;p<0.001). Conclusion(s): These findings revealed that anxiety is common in COVID-19 survivors and is associated with post-discharge patients concerns that may limit patient daily living. This study emphasizes the importance of psychological assessment and follow-up of the COVID-19 survivors, in order to support these patients recovery.

12.
European Psychiatry ; 65(Supplement 1):S377, 2022.
Article in English | EMBASE | ID: covidwho-2153924

ABSTRACT

Introduction: Long-term neuropsychiatric consequences of critical illness are well known. Therefore, it is expected that critical COVID-19 patients might also present several psychiatric symptoms such as depression, with inevitable negative effect on healthrelated quality of life (HRQoL), commonly used as an indicator of illness and treatment impact. Objective(s): To identify depressive symptoms in critical COVID-19 survivors and to examine its association with HRQoL domains. Method(s): This preliminary study involved critical COVID-19 patients admitted into the Intensive Care Medicine Department (ICMD) of a University Hospital, between October and December of 2020. Patients with an ICMD length of stay (LoS)<=24h, terminal illness, major auditory loss, or inability to communicate at the follow-up time were excluded. From 1-2 months after discharge, all participants were evaluated by telephone at follow-up appointment, with Patient Health Questionnaire (PHQ-9) (depression) and EuroQol 5-dimension 5-level EQ-5D-5L (HRQoL). This study is part of the longitudinal MAPA project. Result(s): Eighty-three patients were included with a median age of 63 years (range: 31-86) and the majority were male (63%). The most reported problems on EQ-5D-5L domains were usual activities (82%) and mobility (76%). About 27% presented depressive symptoms, and with more problems of self-care (68%vs41%;p=0.029), pain/discomfort (86%vs49%;p=0.002), and anxiety/depression (96%vs54%;p<0.001). Conclusion(s): These preliminary results are in line in previous studies in critical COVID-19 survivors, with depression being associated with worse HRQoL. Bearing this in mind, follow-up approaches with an early screening and treatment of these psychiatric symptoms will be fundamental to optimize the recovery of these patients.

13.
European Psychiatry ; 65(Supplement 1):S311, 2022.
Article in English | EMBASE | ID: covidwho-2153903

ABSTRACT

Introduction: Severe COVID-19 survivors experience long-term neuropsychiatric morbidity, particularly those who developed delirium, with a negative impact on health-related quality of life (HRQoL). Objective(s): To identify the cases of delirium in severe COVID-19 patients and to describe its association with post-hospital discharge HRQoL. Method(s): In the context of the longitudinal MAPA project, we included adult patients (>= 18 years old) admitted with COVID-19 to the Intensive Care Medicine Department (ICMD) of a Portuguese University Hospital (October 2020-April 2021). Exclusion criteria were: ICMD length of stay <=24h, terminal illness, major auditory loss, or inability to communicate at the time of assessment. Delirium during ICMD stay was ascertained based on patients' clinical records. HRQoL was evaluated using the 5-Level EQ-5D questionnaire (EQ-5D-5L), at a scheduled telephone follow-up appointment on average 1-2 months after hospital discharge. Result(s): Overall, 124 patients were included with a median age of 62 (range: 24-86) years, being mostly male (65%). About 19% had delirium, 42% were deeply sedated and 43% required invasive mechanical ventilation. Most survivors reported problems on the EQ-5D-5L domains: usual activities (85%), mobility (73%) and anxiety/depression (65%). Patients with delirium reported more pain/discomfort (75%vs46%;p=0.011) and considerably anxiety/ depression (83%vs60%;p=0.032). Conclusion(s): These findings pointed that COVID-19 patients who experienced delirium reported worse HRQoL, regarding pain/discomfort and anxiety/depression. This study highlights the importance of not only prevention but also early screening of delirium during hospital stay, as well as the crucial role of the timely interventions at discharge, in order to minimize delirium longterm impacts.

14.
European Psychiatry ; 65(Supplement 1):S310-S311, 2022.
Article in English | EMBASE | ID: covidwho-2153902

ABSTRACT

Introduction: A higher risk of mental health consequences in critical COVID-19 patients is expected due to several reasons, including prolonged mechanical ventilation with exposure to high sedation. In this context, post-discharge depression has been reported in previous COVID-19 studies, with a profound impact on patients' health-related quality of life (HRQoL). Objective(s): To identify depressive symptoms in COVID-19 survivors 1-year after hospital discharge and to analyse its association with HRQoL. Method(s): As part of the longitudinal MAPA project, this study enrolled critical COVID-19 patients admitted in the Intensive Care Medicine Department of a University Hospital (March-May 2020). Participants were assessed through telephone by an intensive care nurse and a psychologist, with the Patient Health Questionnaire (PHQ-9) (depressive symptoms), EuroQol five-dimension fivelevel questionnaire (EQ-5D-5L) and EQ-Visual Analogue Scale (EQ-VAS) (global health status patient record). Result(s): A sample of 55 survivors (median age=66 years;69% males) were included, with 20% showing depressive symptoms. Pain/discomfort (67%) and anxiety/depression (67%) were the most EQ-5D-5L domains reported. Survivors scoring for depression had more problems in all HRQoL areas (mobility:91%vs.48%, p=0.015;self-care:64%vs.27%, p=0.035;usual activities:91%vs.50%, p=0.017;pain/discomfort:100%vs.59%, p=0.010;anxiety/depression:100% vs.59%, p=0.010). Moreover, they had a lower EQ-VAS median, corresponding a worse self-perception of health status (50vs.80, p=0.010). Conclusion(s): Even after 1-year, a significant proportion of survivors presented depressive symptoms with repercussions in all HRQoL dimensions and association with worse self-perception of global quality of life. Taking this in mind, early screening and treatment of depression in COVID-19 survivors will be crucial, minimizing its impact on quality of life.

15.
Estudos de Psicologia ; 39, 2022.
Article in English | Scopus | ID: covidwho-2141001

ABSTRACT

The purpose of this article is to present a reflection on the impact of the Coronavirus Disease 2019 pandemic on the everyday life of Brazilians from different social classes, cultures, and institutions, highlighting the increase in social inequalities aggravated by the context of the pandemic. Critical psychology was used as a theoretical support, in its power to guide and organize social practices aimed at the collective and favor the creation of public policies that are instituted as a tool for confronting and overcoming their current conditions. Particularly, it questions the role of school psychology in the context of the pandemic with the proposition of issues to be faced by the discipline, such as the expansion of threats that affect human development, the main object of action in the area. The text ends by highlighting the role of the environment, especially the school environment, in promoting the development of children and youths so that they can face these new threats, placing school psychology as central in this process and historical moment, in which it must commit to transform reality through collective and collaborative actions. © 2022, Estudos de Psicologia. All Rights Reserved.

16.
Perspectives on Geographical Marginality ; 7:177-189, 2022.
Article in English | Scopus | ID: covidwho-2075277

ABSTRACT

The COVID-19 pandemic has reached dimensions and caused impacts which were never predicted. 2020 will remain in history as the year in which all global economic activity was largely suspended with the tourism sector being the most affected single sector. Managing tourism and strengthening resilience in response to the pandemic has gained an increasing importance in a globalised world, where changes and interrelationships have become increasingly complex. The COVID-19 pandemic has shown that natural risks are not the only factors responsible for the marginalisation of many touristic areas. In this chapter, the impact of the pandemic on tourism, and what it means for our understanding of resilience and marginality is examined, before looking at the situation in Porto. In this city, literary tourism is explored as a valuable new and alternate form of tourism in a post-pandemic world to address marginalisation. The starting point for the discussion is about the possibility of inviting tourists to Porto through a focus on literature, and, in that sense, we will present a reflection about literary tourism as an innovative tourist opportunity that can expand touristic offer to new audiences and minimise the marginalisation effects caused by the lockdown imposed by the pandemic. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

17.
Psicologia Conocimiento Y Sociedad ; 12(2):29-51, 2022.
Article in Portuguese | Web of Science | ID: covidwho-2072441

ABSTRACT

This article presents the results of a scientific initiation research that aimed to reflect on the difficulties and facilities of remote work with people with intellectual disabilities. Due to the pandemic scenario, in front of COVID-19, the five meetings held took place remotely, using the Google Meet platform. Six adults diagnosed with intellectual disabilities participated, who attend a Civil Society Organization that provides a support service for Adult Life, with programs that seek to support social inclusion, located in the city of Campinas/SP. The analysis was based on the theoretical-methodological assumptions of Historical-Cultural Psychology, especially those of Vigotski. The results indicate that difficulties in communicating, sharing meanings and handling technology are obstacles to the development of people with disabilities. However, it is concluded that the activity of telling and listening to stories enhances spaces for development and sharing of sense and meaning, without denying the differences and adaptive needs, but as a possibility of joint construction of possible paths for an effective inclusion.

18.
Probiotics in the Prevention and Management of Human Diseases: A Scientific Perspective ; : 41-58, 2022.
Article in English | Scopus | ID: covidwho-2060207

ABSTRACT

The immune system is a complex architecture of a collective and coordinated network regulated by various pathways to thermodynamically maintain immune homeostasis. The gut microbiota plays a pivotal role that offers significant stimuli (i.e., gut-brain, gut-lung, and gut-liver axis) for both innate and adaptive immunity, mediating immune and metabolic homeostasis. An intricate correlation between changes in the gut microbiota (dysbiosis) and common diseases/disorders have been attributed to the invasion of pathogens, constant use of antibiotics, and hypercytokinemia—a hallmark of immune homeostasis imbalance. These factors contribute to the severity of inflammatory diseases such as cardiovascular diseases, neurological disorders, and of late the coronavirus disease, Covid-19. Probiotics (Lactobacillus spp. and Bifidobacterium spp.) have been considered as alternative and/or adjuvant therapeutic in restoring the balance of gut microbiota for maintaining immune homeostasis and integrity. The probiotics catalyze dietary fibers and proteins to generate short-chain fatty acids and tryptophan to promote antiinflammatory cytokines, reduce epithelium permeability, reinforcing immunity in the gut mucosa, and regulating the systemic immune response. Herein, we review our overarching understanding of current applications of probiotics in amelioration of gut microbiome, and the improvement of gut barrier function and maintaining immune homeostasis. We also highlight clinical trials on probiotics with reported results for the treatment of inflammatory diseases. Additionally, the looming global Covid-19 pandemic makes it prudent to highlight the role of probiotics in both the innate and adaptive human immune responses, especially amid the Covid-19 vaccination paradigm. © 2022 Elsevier Inc. All rights reserved.

19.
23rd International Conference on Enterprise Information Systems, ICEIS 2021 ; 2:189-196, 2021.
Article in English | Scopus | ID: covidwho-2045221

ABSTRACT

Due to the consequences of the pandemic caused by the new coronavirus, home office has been adopted by companies to enable the continuity of their activities in an emergency and preventive feature. A survey has been conducted through interviews with ten project managers from multinational IT companies, in order to analyse and understand how project management processes are performed during the development of software projects in home office format. Impacts were identified in different aspects, positively and negatively, in the project management processes. Concerning software development teams, it was possible to observe that the greatest impact is related to communication and start using online tools for daily activities. We have also learned that there are differences between the consequences of the home office and consequences of the pandemic. And there are permanent changes and lessons learned during the management in pandemic. Copyright © 2021 by SCITEPRESS - Science and Technology Publications, Lda.

20.
Revista Brasileira de Epidemiologia ; 25, 2022.
Article in English | EMBASE | ID: covidwho-1938485

ABSTRACT

Objective: The aim of this study was to analyze the spatial distribution of outpatient physical therapy rehabilitation services and associate it with the geographic location of users’ households. Methods: The public physical therapy rehabilitation services and addresses of users’ households in Campo Grande (MS) were georeferenced in 2017-2019. Results: Five physical therapy clinics were identified to supply the demand of 31,774 scheduled users. Most services are in the most central regions of the city, while most users reside in peripheral areas. Conclusion: An assistance gap in Physical therapy care was identified, with a restricted supply of services to meet demands and a geographic barrier, since the services are far from the users’ households. Physical rehabilitation must be a priority in the country’s public health, especially nowadays, where demands for rehabilitation of a significant number of Brazilians who evolved with sequelae of COVID-19 are so present.

SELECTION OF CITATIONS
SEARCH DETAIL